Christine Courteix






University of Clermont Auvergne  (France), PhD in Neuropsychopharmacology

University of Minnesota (USA), Post-Doctoral fellow



Faculty of Pharmacy

28, Place Henri-Dunant - 63000 Clermont-Ferrand (France)


+33 4 73 17 80 16

Research Interest:

Pathophysiology and pharmacology of neuropathic pain. By combining molecular, cell biology, biochemical (microdialysis) and behavioral approaches, our team is deciphering the role of 5-HT2A and 5-HT6 serotonin receptors and/or their signalling pathways in order to propose alternative strategies for the treatment of neuropathic pain and associated comorbidities.

Key words: Neuropathic pain, serotonin, antidepressants, 5-HT2A receptor, 5-HT6 receptor

Technical expertise:

- Spinal microdialysis in awake rats;

- Animal behavioural tests (nociception, anxiety, cognition, depression);

- Experimental models of neuropathic pain (STZ-, SNL-, CC-I, Oxaliplatin-induced neuropathic pain in rats)

Recent Publications:

-C. CHENAF, E. CHAPUY, F. LIBERT, F. MARCHAND, C. COURTEIX, M. BERTRAND, C. GABRIEL, E.MOCAËR, A. ESCHALIER, N. AUTHIER. Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. Pain, 2017; 158(1): 149-160.


--A. DUPUIS, AS. WATTIEZ, J.PINGUET, D. RICHARD, F. LIBERT, M. CHALUS, Y. AISSOUNI, B. SION, D. ARDID, P. MARIN, A. ESCHALIER, C. COURTEIX. Increasing spinal 5-HT2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release. Pharmacol Res.,  2017; 118: 93-103.

-AS. WATTIEZ, A. DUPUIS, AM. PRIVAT, M. CHALUS, E. CHAPUY, Y. ASSOUNI, A. ESCHALIER, C. COURTEIX. Disruption of 5-HT2A-PDZ protein interaction differently affects the analgesic efficacy of SSRI, SNRI and TCA in the treatment of traumatic neuropathic pain in rats. Neuropharmacol., 2017; 125: 308-318

-LJ. RONDON, MC. FARGES, N. DAVIN, B. SION, AM. PRIVAT, MP. VASSON, A. ESCHALIER, C. COURTEIX. L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration. Eur. J Nutr 2017 doi: 10.1007/s00394-017-1508-x.



Un cœur en Auvergne pour l'Institut Analgesia, premier pôle de recherche et d'innovation sur le traitement de la douleur

2014 - Ducki S, Eschalier A, Corteval A, Bennis K, Ripoche I, Busserolles J, Courteix C L'actualité chimique n°395 - pp 29-33

Disruption of 5-HT2A Receptor-PDZ Protein Interactions Alleviates Mechanical Hypersensitivity in Carrageenan-Induced Inflammation in Rats

2013 - Wattiez AS,Pichon X,Dupuis A,Hernandez A,Privat AM,Aissouni Y,Chalus M,Pelissier T,Eschalier A,Marin P,Courteix C PLoS One n°8(9) - e74661

Identification of PDZ-ligands by docking-based virtual screening for the development of novel analgesic agents

2013 - Bouzidi N,Deokar H,Vogrig A,Boucherle B,Ripoche I,Abrunhosa-Thomas I,Dorr L,Wattiez AS,Lian L,Marin P,Courteix C,Ducki S Bioorg Med Chem Lett. n°23(9) - pp 2624-7

Animal Models of Toxic and Metabolic Neuropathic pain

2013 - Courteix C,Ferrier J,Marchand F,Authier N,Dupuis A,Balayssac D,Eschalier A Pain Models: Translation Relevance and Applications

Structure-based Design of PDZ ligands as inhibitors of 5-HT2A receptor/PSD-95 PDZ1 Domain possessing antihyperalgesic activity

2013 - Vogrig A,Dorr L,Bouzidi N,Boucherle B,Wattiez AS,Gassier E,Vallon G,Ripoche I,Abrunhosa-Thomas I,Marin P,Nauton L,Thery V,Courteix C,Lian L,Ducki S ACS Chem Biol n°8(10) - pp 2209-16

Rodent models of painful diabetic neuropathy : what can we learn from them ?

2012 - Wattiez AS,Barriere DA,Dupuis A,Courteix C Diabetes and Metabolism n°S5 - pp 2-12

Does the streptozocin diabetic rat provide a suitable model for studying painful diabetic neuropathy ?

2012 - Wattiez AS,Dupuis A,Courteix C Douleur-Analgésie n°25 - pp 38-45

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

2011 - Descoeur J,Pereira V,Pizzoccaro A,Francois A,Ling B,Maffre V,Couette B,Busserolles J,Courteix C,Noel J,Lazdunski M,Eschalier A,Authier N,Bourinet E EMBO Mol Med n°3(5) - pp 266-78

Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?

2011 - Wattiez AS,Libert F,Privat AM,Loiodice S,Fialip J,Eschalier A,Courteix C Br J Pharmacol n°163(4) - pp 792-803

Protéines à domaines PDZ : cibles potentielles pour le traitement de la douleur chronique

2011 - Wattiez AS,Courteix C Douleurs Evaluation-Diagnostic-Traitement n°12 - pp 7-14

Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain

2010 - Pichon X,Wattiez AS,Becamel C,Ehrlich I,Bockaert J,Eschalier A,Marin P,Courteix C Mol Ther n°18(8) - pp 1462-70

Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain

2010 - Rondon L,Privat AM,Daulhac L,Davin N,Mazur A,Fialip J,Eschalier A,Courteix C J Physiol n°588(Pt 21) - pp 4205-15

Téléphone : +33473178016