CV - CHALUS Maryse






Assistant Engineer


DUT Génie biologique



Faculty of Medicine - Laboratoire d’Anatomie et Organogenèse – UMR INSERM 1107

28 place Henri Dunant – BP 38 – 63001 Clermont-Ferrand (France)


+33 4 73 17 80 91

Research Interest:

Non-invasive measurement of cerebrospinal fluid (CSF) pressure using elecrophysiological monitoring of cochlear external ciliary cells. Diagnosis of ventriculoperitoneal shunt malfunction using monitoring of cochlear external ciliary cells in postural tests. Anatomy and histology of meningeal structures and CSF spaces.

Brain and spinal cord white matter repair. Neuroprotection and neurorepair. In vitro and in vivo studies. Assessment of SCO-spondin derived molecules in experimental spinal cord injury.

Technical expertise:


- Cellular culture, cell lines, primary cultures and cell based assays

- Animal experimentation, brain stereotactic procedures on rat models, microneurosurgery ,microdialysis

- Immunohistochemistry

- Biochemistry

Recent Publications:

Dupuis A, Wattiez AS, Pinguet J, Richard D, Libert F, Chalus M, Aissouni Y, Sion B, Ardid D, Marin P, Eschalier A, Courteix C.

Increasing spinal 5-HT2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release.

Pharmacol Res. 2016 Sep 20. pii: S1043-6618(16)30956-2.


Ferrier J, Bayet-Robert M, Dalmann R, El Guerrab A, Aissouni Y, Graveron-Demilly D, Chalus M, Pinguet J, Eschalier A, Richard D, Daulhac L, Marchand F, Balayssac D. Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.  J Neurosci.  2015  16; 35(50):16418-30.


Morel V, Pickering G, Etienne M, Dupuis A, Privat AM, Chalus M, Eschalier A, Daulhac L. Low doses of dextromethorphan have a beneficial effect in the treatment of neuropathic pain. Fundam Clin Pharmacol. 2014 28(6):671-80.


Wattiez AS, Pichon X, Dupuis A, Hernández A, Privat AM, Aissouni Y, Chalus M, Pelissier T, Eschalier A, Marin P, Courteix C. Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. PLoS One. 2013 18; 8(9):e74661.


Morel V, Etienne M, Wattiez AS, Dupuis A, Privat AM, Chalus M, Eschalier A, Daulhac L, Pickering G. Memantine, a promising drug for the prevention of neuropathic pain in rat. Eur J Pharmacol.  2013  5;721(1-3):382-90.


Noseda R, Constandil L, Bourgeais L, Chalus M, Villanueva L. Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci.  2010   27;30(43):14420-9.

Phone : +33473178091